Completed Studies

Researcher-initiated studies
1. Yin WH, Wu CC, Chen JW. Registry of Lipid Control and the Use of Lipid-lowering Drugs for Secondary Prevention of Cardiovascular Events in Patients with Established Atherosclerotic Disease in Taiwan: Rationality and Methods. International Journal of Gerontology 2012; 6:241-6. 
2. Wu CK, Huang YT, Lee JK, Chiang LT, Chiang FT, Huang SW, Lin JL, Tseng CD, Chen YH, Tsai CT. Cardiac Myosin Binding Protein C and MAP-Kinase Activating Death Domain-Containing Gene Polymorphisms and Diastolic Heart Failure. PLoS One. 2012;7(4):e35242. Epub 2012 Apr 17.
3. Lin CY, Wu CK, Yeong EK, Lin HH, Huang YT, Lee JK, Lin YH, Chiang FT, Tang YB, Tsai CT. Prognostic significance of left ventricular diastolic function in burn patients. Shock. 2012 May;37(5):457-62.
4. Chen CY, Chuang SY, Fang CC, Huang LC, Hsieh IC, Pan WH, Yeh HI, Wu CC, Yin WH, Chen JW. Gender difference in statin intervention on blood lipid control among patients with coronary heart disease. International Journal of Gerontology. 2013;7(2): 116-121.
5. Chen YP, Chang KC, Tseng WK, Yin WH, Chen JW, Lee YT, Wu CC. Increased Rosuvastatin Dose versus Concomitant Fenofibrate and Rosuvastatin Therapy to Achieve Lipid Goal in Patients with Diabetes or Atherosclerosis with Metabolic Syndrome. Acta Cardiology Sinica 2013;29:421-428.
6. Wu YW, Lee CM, Liu YB, Wang SS, Huang HC, Tseng WK, Jui HY, Wang SY, Horng HE, Yang HC, Wu CC. Usefulness of magnetocardiography to detect coronary artery disease and cardiac allograft vasculopathy. Circ J. 2013;77(7):1783-90. Epub 2013 Apr 19.
7. Yang SY, Chieh JJ, Yang CC, Liao SH, Chen HH, Horng HE, Yang HC, Hong CY, Chiu MJ, Chen TF, Huang KW, and Wu CC. Clinic applications in assaying ultra-low-concentration bio-markers using HTS SQUID-based AC magnetosusceptometer. IEEE Trans. Appl. Supercond. 2013:23,1600604. 
8. Jeng JS, Yin WH, Huang CC, Chuang SY, Yeh HI, Fang CC, Lin TH, Wang KY, Tseng WK, Huang LC, Ueng KC, Hsieh IC, Li YH, Pan WH, Wu CC, Jaw-Wen Chen, on behalf of the Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators. Guideline-adherent therapy in patients with cardiovascular diseases in Taiwan. J Formos Med Assoc. 2013 Nov 22. pii: S0929-6646(13)00362-8. doi: 10.1016/j.jfma.2013.10.007. [Epub ahead of print]
9. Chen CA, Lu MY, Peng SF, Lin KH, Chang HH, Yang YL, Jou ST, Lin DT, Liu YB, Horng HE, Yang HC, Wang JK, Wu MH, Wu CC. Spatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major. PLoS One. 2014; 9 (1): e86524. 
10. Chen CY, Chuang SY, Fang CC, Huang LC, Hsieh IC, Pan WH, Yeh HI, Wu CC, Yin WH, Chen JW. Gender disparities in optimal lipid control among patients with coronary artery disease. Journal of atherosclerosis and thrombosis. 2014; 21 Suppl 1:S20-8.
11. Lin TH, Chuang SY, Chu CY, Lee WH, Hsu PC, Su HM, Li YH, Fang CC, Wang KY, Tseng WK, Li AH, Ueng KC, Hsieh IC, Huang LC, Wang CH, Pan WH, Yeh HI, Wu CC, Yin WH, Chen JW. The Impact of Chronic Kidney Disease on Lipid Management and Goal Attainment in Patients with Atherosclerosis Diseases in Taiwan. Int. J. Med. Sci. 2014; 11(4): 381-388.
12. Wu YW, Lin LC, Tseng WK, Liu YB, Kao HL, Lin MS, Huang HC, Wang SY, Horng HE, Yang HC, Wu CC. QT(c) Heterogeneity in Rest Magnetocardiography is Sensitive to Detect Coronary Artery Disease: In Comparison with Stress Myocardial Perfusion Imaging. Acta Cardiol Sin. 2014; 30(5): 445-454.
13. Wu CK, Yang YH, Lin TT, Tsai CT, Hwang JJ, Lin JL, Chen PC, Chiang FT, Lin LY. Statin use reduces the risk of dementia in elderly patients: a nationwide data survey and propensity analysis. J Intern Med. 2015 Mar;277(3):343-52
14. Ho LT, Yin WH, Chuang SY, Tseng WK, Wu YW, Hsieh IC, Lin TH, Li YH, Huang LC, Wang KY, Ueng KC, Fang CC, Pan WH, Yeh HI, Wu CC (Correspondence), Chen JW, on behalf of the Taiwanese Secondary Prevention for Patients with AtheRosCLErotic Disease (T-SPARCLE) Registry Investigators.  Determinants for Achieving the LDL-C Target of Lipid Control for Secondary Prevention of Cardiovascular Events in Taiwan. PLoS One. 2015; 10 (3): e0116513.
15. Chang YC, Wu CC, Lin CH, Wu YW, Yang YC, Chang TJ, Jiang YD, Chuang LM. Early myocardial repolarization heterogeneity is detected by magnetocardiography in diabetic patients with cardiovascular risk factors. PLoS One. 2015; 10 (7): e0133192.
16. Lin TH, Lai WT, Kuo CT, Hwang JJ, Chiang FT, Chang SC, Chang CJ. Additive effect of in-hospital TIMI bleeding and chronic kidney disease on 1-year cardiovascular events in patients with acute coronary syndrome: Data from Taiwan Acute Coronary Syndrome Full Spectrum Registry. Heart Vessels. 2015 Jul;30(4):441-50.
17. Tsai CT, Hsieh CS, Chang SN, Chuang EY, Juang JM, Lin LY, Lai LP, Hwang JJ, Chiang FT, Lin JL. Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. J Med Genet. 2015 Jan;52(1):28-36.
18. Chiang CE, Wang TD, Ueng KC, Lin TH, Yeh HI, Chen CY, Wu YJ, Tsai WC, Chao TH, Chen CH, Chu PH, Chao CL, Liu PY, Sung SH, Cheng HM, Wang KL, Li YH, Chiang FT, Chen JH, Chen WJ, Yeh SJ, Lin SJ. 2015 guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension. J Chin Med Assoc. 2015 Jan;78(1):1-47.
19. Wu CK, Yang YH, Juang JM, Wang YC, Tsai CT, Lai LP, Hwang JJ, Chiang FT, Chen PC, Lin JL, Lin LY. Effects of angiotensin converting enzyme inhibition or angiotensin receptor blockade in dialysis patients: a nationwide data survey and propensity analysis. Medicine (Baltimore). 2015 Jan;94(3):e424.
20. Lin TT, Yang YH, Liao MT, Tsai CT, Hwang JJ, Chiang FT, Chen PC, Lin JL, Lin LY. Primary prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with end-stage renal disease undergoing dialysis. Kidney Int. 2015 Aug;88(2):378-85.
21. Wu CK, Lee JK, Wu YF, Tsai CT, Chiang FT, Hwang JJ, Lin JL, Hung KY, Huang JW, Lin JW. Left ventricular diastolic dysfunction in peritoneal dialysis: a forgotten risk factor. Medicine (Baltimore). 2015 May;94(20):e819.
22. Juang JM, Tsai CT, Lin LY, Liu YB, Yu CC, Hwang JJ, Chen JJ, Chiu FC, Chen WJ, Tseng CD, Chiang FT, Yeh HM, Sherri Yeh SF, Lai LP, Lin JL. Unique clinical characteristics and SCN5A mutations in patients with Brugada syndrome in Taiwan. J Formos Med Assoc. 2015 Jul;114(7):620-6. 
23. Ho LT, Lin LY, Yang YH, Wu CK, Juang JM, Wang YC, Tsai CT, Lai LP, Hwang JJ, Chiang FT, Lin JL, Chen PC. Statin therapy lowers the risk of new-onset atrial fibrillation in patients with end-stage renal disease. Int J Cardiol. 2015 Dec 15;201:538-43.
24. Lin TT, Chiang JY, Liao MT, Tsai CT, Hwang JJ, Chiang FT, Lin JL, Lin LY. Primary prevention of atrial fibrillation with beta-blockers in patients with end-stage renal disease undergoing dialysis. Sci Rep. 2015 Dec 8;5:17731.
25. Lu DY, You LK, Sung SH, Cheng HM, Lin SJ, Chiang FT, Chen CH, Yu WC. Abnormal Pulsatile Hemodynamics in Hypertensive Patients With Normalized 24-Hour Ambulatory Blood Pressure by Combination Therapy of Three or More Antihypertensive Agents. J Clin Hypertens (Greenwich). 2015 Dec 10.
26. Lin KH, Chen YS, Chou NK, Huang SJ, Wu CC, Chen YY. The Associations Between the Religious Background, Social Supports, and Do-Not-Resuscitate Orders in Taiwan: An Observational Study. Medicine (Baltimore). 2016 Jan;95(3):e2571.
27. Yin WH, Chen P, Yeh HI, Wang KY, Hung YJ, Tseng WK, Wen MS, Wu TC, Wu CC, Cheng SM, Chen JW. Combination With Low-dose Dextromethorphan Improves the Effect of Amlodipine Monotherapy in Clinical Hypertension: A First-in-human, Concept-proven, Prospective, Dose-escalation, Multicenter Study. Medicine (Baltimore). 2016 Mar;95(12):e3234.
28. Lin KH, Chen YS, Chou NK, Huang SJ, Wu CC, Chen YY. The Associations Between the Religious Background, Social Supports, and Do-Not-Resuscitate Orders in Taiwan: An Observational Study. Medicine (Baltimore). 2016 Jan;95(3):e2571.

Collaborated International Studies
1. NAVIGATOR Study Group, Holman RR, Haffner SM, McMurray JJ, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamas G, Tognoni G, Tuomilehto J, Villamil AS, Vozar J, Califf RM. Effect of nateglinide on the incidence of diabetes and cardiovascular events. N Engl J Med. 2010 Apr 22;362(16):1463-76. Epub 2010 Mar 14. Erratum in: N Engl J Med. 2010 May 6;362(18):1748.
2. Hokusai-VTE Investigators, Büller HR, Décousus H, Grosso MA, Mercuri M, Middeldorp S, Prins MH, Raskob GE, Schellong SM, Schwocho L, Segers A, Shi M, Verhamme P, Wells P. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med. 2013 Oct 10;369(15):1406-15. doi: 10.1056/NEJMoa1306638. Epub 2013 Aug 31.
3. Kario K1, Sun N, Chiang FT, Supasyndh O, Baek SH, Inubushi-Molessa A, Zhang Y, Gotou H, Lefkowitz M, Zhang J. Efficacy and safety of LCZ696, a first-in-class angiotensin receptor neprilysin inhibitor, in Asian patients with hypertension: a randomized, double-blind, placebo-controlled study. Hypertension. 2014 Apr;63(4):698-705. doi: 10.1161/HYPERTENSIONAHA.113.02002. Epub 2014 Jan 20.
4. Gheorghiade M, Greene SJ, Butler J, Filippatos G, Lam CS, Maggioni AP, Ponikowski P, Shah SJ, Solomon SD, Kraigher-Krainer E, Samano ET, Müller K, Roessig L, Pieske B; SOCRATES-REDUCED Investigators and Coordinators. Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial. JAMA. 2015 Dec 1;314(21):2251-62. doi: 10.1001/jama.2015.15734. 
5. Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, Darius H, Lewis BS, Ophuis TO, Jukema JW, De Ferrari GM, Ruzyllo W, De Lucca P, Im K, Bohula EA, Reist C, Wiviott SD, Tershakovec AM, Musliner TA, Braunwald E, Califf RM; IMPROVE-IT Investigators. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med. 2015 Jun 18;372(25):2387-97. doi: 10.1056/NEJMoa1410489. Epub 2015 Jun 3.
6. Pollack CV Jr1, Reilly PA, Eikelboom J, Glund S, Verhamme P, Bernstein RA, Dubiel R, Huisman MV, Hylek EM, Kamphuisen PW, Kreuzer J, Levy JH, Sellke FW, Stangier J, Steiner T, Wang B, Kam CW, Weitz JI. Idarucizumab for Dabigatran Reversal. N Engl J Med. 2015 Aug 6;373(6):511-20. doi: 10.1056/NEJMoa1502000. Epub 2015 Jun 22.
7. Cicero AF1, Tartagni E, Ertek S. Efficacy and safety profile of evolocumab (AMG145), an injectable inhibitor of the proprotein convertase subtilisin/kexin type 9: the available clinical evidence. Expert Opin Biol Ther. 2014 Jun;14(6):863-8. doi: 10.1517/14712598.2014.902929. Epub 2014 Mar 24.
8. Gheorghiade M, Greene SJ, Butler J, Filippatos G, Lam CS, Maggioni AP, Ponikowski P, Shah SJ, Solomon SD, Kraigher-Krainer E, Samano ET, Müller K, Roessig L, Pieske B; SOCRATES-REDUCED Investigators and Coordinators. Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial. JAMA. 2015 Dec 1;314(21):2251-62.

Patents:

Category

Name

Country

Patent Code

Inventors

Owner

Issued Date

Grant

System and method for evaluating cardiovascular performance in real time and characterized by conversion of surface potential into multi-channels

USA

US 8571645

 

Chau-Chung Wu, Chii-Wann Lin, Chien-Sheng Liu

 

National Taiwan University

October 29, 2013

Grant

Method of examining dynamic cardiac electromagnetic activity and detection of cardiac functions using results thereof

USA

US 7957787

 

Horng; Herng-Er,

Wu; Chau-Chung,

Yang; Hong-Chang,

Yang; Shieh-Yueh

National Taiwan Normal University

June 7, 2011

Grant

Method of examining dynamic cardiac electromagnetic activity and detection of cardiac functions using results thereof

USA

US 7805179

Horng; Herng-Er,

Wu; Chau-Chung,

Yang; Hong-Chang,

Yang; Shieh-Yueh

National Taiwan Normal University

September 28, 2010

Grant

Sensor system of surface plasmon resonance (SPR) and measuring method thereof

USA

US 6661520

 

Lin; Chii-Wann, Huang; Chi-Yu, Chiu; Jyh-Perng, Liou; Ying-Tsuen, Shiue; Shuen-Chen, Kuo; Te-Son, Huang; Long-Sun, Chang; Pei-Zen, Yang; Lung-Jieh, Wu; Chau-Chung, Lin; Shiming, Lee; Chih-Kung

National Taiwan University

December 9, 2003